Solchemia provides custom synthesis of linkers for antibody-drug conjugates (ADCs), including both cleavable and non-cleavable designs for optimal stability, biocompatibility, and controlled drug release.
Our ADC linker customization services cover every domain of the molecular structure, including the attachment site, linker backbone, spacer unit, and payload. We provide access to an extensive portfolio of chemical building blocks, available for selection on a tailored basis. Furthermore, we offer custom synthesis capabilities to accommodate any additional modifications required, whether on the linker or spacer regions.
ATTACHMENT SITES
Maleimide
N-hydroxysuccinimide (NHS)
Bis(vinylsulfonyl)-piperazine (BVP)
N‑Methyl‑N‑phenylvinyl-sulfonamide
CLEAVABLE LINKERS
pH sensitive: Hydrazones
Reduction sensitive: Disulfides
Enzymatically: Peptide based,
β-glucoronides, phosphates
Photochemically: O-Nitrobenzyl
NON-CLEAVABLE LINKERS
Thioethers
Maleimido caproyl
Triazoles
Alkynes
Piperazines
SPACERS
Para-aminobenzyl carbamate (PABC)
7-amino-3-hydroxyethyl-
coumarin (7-AHC)
Polyethylene glycols (PEGs)
PAYLOADS
Maytansinoids
MMAE
MMAF
Calicheamicin
Doxorubicin
We deliver high-purity linkers with complete analytical documentation and characterization (including HPLC, NMR, and mass spectrometry), ensuring full traceability and reproducibility. Our scalable processes —from milligram to gram quantities— support both early discovery and preclinical development needs.
Whether you need a well-established structure or a fully novel linker concept, Solchemia provides fast, reliable, and flexible solutions to accelerate your ADC development. Contact us today to discuss your project or request a custom quote.
